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采用硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱及半制备HPLC等色谱方法对番荔枝科瓜馥木属植物瓜馥木Fissistigma oldhamii中生物碱类化学成分进行了系统的分离与纯化,运用理化分析及NMR、MS等现代波谱学方法对其结构进行鉴定。从瓜馥木枝叶的总生物碱提取物中共分离得到14个生物碱类化合物,分别鉴定为:去甲头花千金藤二酮(1)、巴婆碱(2)、毛叶含笑碱(3)、六驳碱(4)、异紫堇定碱(5)、番荔枝叶碱(6)、甲氧番荔枝碱(7)、N-methylbuxifoline(8)、aristolactam AIIIa(9)、piperumbellactam A(10)、goniopedaline(11)、aristolactam BIII(12)、鹅掌揪碱(13)和salutaridine(14)。其中化合物3~5,8,10,11和14为首次从瓜馥木属植物中分离得到。
The chemical constituents of alkaloids from Fusarium graminearum Fissistigma oldhamii were systematically isolated and purified by silica gel column chromatography, ODS column chromatography, Sephadex LH-20 column chromatography and semi-preparative HPLC. The physicochemical analysis and NMR, MS and other modern spectroscopy methods to identify its structure. A total of 14 alkaloids were isolated from the total alkaloid extracts of the stems and leaves of G. melilotoides and identified as: Desmodium spp. (1) ), Hexamine (4), iso-cinerate (5), bentoine (6), trioclnidine (7), N-methylbuxifoline (8), aristolactam AIIIa (9), piperumbellactam A (10), goniopedaline (11), aristolactam BIII (12), geluotone (13) and salutaridine (14). Compounds 3 ~ 5, 8, 10, 11 and 14 were isolated from melon for the first time.