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复方硫黄洗剂和炉甘石洗剂是常用的外用混悬剂。由于这两种洗剂中主要成分都是粉剂,配制后不易混悬均匀,而往往沉淀于容器底部结块,再分散能力差,摇不匀,用时不好涂擦,影响治疗效果。为了改变这种情况,我们使用羧甲基纤维素钠、司盘-80、吐温等作助悬剂,对这两种洗剂分别设计4种处方进行试验,以常用处方进行对照。配制当时和分别放置20日(硫黄洗剂)和25日(炉甘石洗剂)后观察结果。结果两种洗剂采用下列处方可达到满意效果:即悬浮物不分层,沉淀在容器底部的药物不结块,再分散能力良好,液体粘稠适度,便于涂布,比常用处方效果好。
Compound sulfur lotion and calamine lotion are commonly used topical suspensions. Because these two lotion are the main ingredients are powder, the preparation is not easy to suspend evenly, and often precipitate in the bottom of the container agglomeration, poor redispersibility, shaking uneven, with a bad rub, affect the treatment effect. In order to change this situation, we use sodium carboxymethyl cellulose, Span-80, Tween and other suspending agents for the two kinds of lotion were designed four kinds of prescription for testing, the commonly used prescriptions for control. The preparation was then placed on the 20th (sulfur lotion) and 25 (calamine lotion) after the observation. Results The two formulations showed satisfactory results with the following prescriptions: the suspension was not delaminated, the drug precipitated at the bottom of the container did not agglomerate, the redispersibility was good, the liquid was viscous and moderate, and the coating was easy to apply. The effect was better than the common prescription.