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目的 :对广西近三年来狂犬病回升作流行病学分析。方法 :采用自治区狂犬病疫情资料及流行区各地市县级防疫站犬伤门诊防治资料统计分析。用 EIA试剂盒检测人血清抗狂犬病毒抗体。结果 :狂犬病疫情回升主要是在山区新疫区 ,发病人数占全区的一半。新疫区犬伤后狂犬病发病率为 0 .45 %高于老疫区 0 .2 4%的近 2倍。近三年狂犬病毒疫苗免后抗体阳性率偏低 (6 8%～ 81% )。犬密度高 ,犬免疫率 <10 %。新疫区发现不典型狂犬病例和麻痹型狂犬病例 ;狂犬野毒株糖蛋白基因核苷酸序列分析与疫苗株有 10 %～ 15 %差异。结论 :新疫区狂犬病流行与犬密度高 ,且缺乏管理 ,犬免疫率低有关 ,也可能与流行株的抗原性变异有关。
Objective: To analyze the epidemiology of rabies in Guangxi in recent three years. Methods: The data of epidemic situation of rabies in autonomous region and statistical analysis of prevention and treatment data of canine outpatients in epidemic prevention stations in all epidemic areas in different endemic areas were used. Human serum anti-rabies antibodies were tested using the EIA kit. Results: The rabies epidemic rebounded mainly in the new affected areas of mountainous areas, accounting for about half of the area. The prevalence of rabies in dogs in newly infected areas was 0.45% higher than that in rabies vaccines of 0.24% of the old areas. In the past three years, the positive rate of rabies virus-free antibody was low (68% -81%). Dog density, dog immunization rate <10%. The new epidemic area found atypical rabies cases and paralytic rabies cases; wild rabies virus strains of glycoprotein nucleotide sequence analysis and vaccine strains have 10% to 15% difference. Conclusion: The prevalence of rabies in the new epidemic area is related to the high density of dogs, lack of management and low immunization rate of dogs, and may also be related to the antigenic variation of epidemic strains.