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作者研究哮喘患者皮质激素吸入治疗后气道生理和免疫病理改变,探讨皮质激素对细胞介导的气道免疫反应的作用。病人和方法6例确诊的哮喘患者,中位年龄38.5(22～63)岁。近2个月内无呼吸道感染及哮喘急性发作病史,除维持吸入β_2激动剂缓解症状外,未用皮质激素及其它药物治疗。所有患者均行肺功能检查、组胺支气管激发试验及测定吸入舒喘灵(400μg)后的支气管扩张反应(测定FEV_1),并行纤维支气管镜检查,取右下叶亚段支气管活检做免疫病理分析。随后应用皮质激素治疗,通过雾化吸入器定量吸入丁
The author studied the airway physiology and immunopathological changes after inhaled corticosteroid treatment in asthmatic patients and explored the effect of corticosteroids on cell-mediated airway immune responses. Patients and Methods Six patients with confirmed asthma had a median age of 38.5 (22-63) years. In the recent 2 months, there was no history of respiratory infection and acute exacerbation of asthma. Corticosteroids and other drugs were not used except for inhaled β 2 agonists to relieve symptoms. All patients underwent pulmonary function tests, histamine bronchial provocation test and bronchodilator response after inhaled salbutamol (400 μg) (FEV 1 was measured). Bronchial biopsy was performed in the right lower lobe and bronchial biopsy for immunohistopathology . Subsequent application of corticosteroids, inhaled by inhalation dosimetry