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用凝胶色谱法研究了螯合剂使结合在人血清白蛋白上的铜(Ⅱ)活动化的能力,若用在螯合剂存在时和无螯合剂存在时蛋白部分结合金属量之比作为表征活动化能力的参数,有如下顺序:Trien>DTPA>EDTA>EGTA>NTA>IDA除Trien和DTPA外,其他几种螯合剂的活动化能力的对数值与其相应的条件稳定常数的对数值之间有一线性关系.Trien和DTPA的反常被认为与复杂的反应历程有关,这可能涉及三元配合物的形成。
The ability of a chelating agent to mobilize copper (II) bound to human serum albumin has been studied by gel chromatography. If the ratio of the amount of partially bound metal in the presence or absence of a chelator is used as a characterization activity The order of the activation energy is as follows: Trien> DTPA> EDTA> EGTA> NTA> IDA In addition to Trien and DTPA, there is a relationship between the logarithm of the mobilizing power of several chelating agents and their corresponding logarithm of the steady- Linear relationships. The abnormalities of Trien and DTPA are thought to be related to complex reaction processes, which may involve the formation of ternary complexes.