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采用放射免疫检测方法，观察了强啡肽（Ｄｙｎ）和苯环利定（ＰＣＰ）对高血压大鼠（ＳＨＲ）的环腺苷酸（ｃＡＭＰ）生成系统的影响．结果表明：Ｄｙｎ剂量依赖地降低ＳＨＲ和非高血压大鼠（ＷＫｙ）的外周血管中ｃＡＭＰ的含量，并且对ＳＨＲ的ｃＡＭＰ生成系统的抑制作用大于ＷＫｙ（Ｐ＜０．０５）；相反地，ＰＣＰ剂量依赖地升高ＳＮＲ和ＷＫｙ的外周血管中的ｃＡＭＰ的含量，对ＳＨＲ的ｃＡＭＰ生成系统的激活作用小于ＷＫｙ（Ｐ＜０．０５）。这些观察表明：１．Ｄｙｎ和ＰＣＰ通过抑制或激活环腺苷酸生成系统对ＳＨＲ产生作用。２．ＳＨＲ和ＷＫｙ的外周动脉对Ｄｙｎ和ＰＣＰ的敏感性不同。Ｐ＜０．０１ｖｓＷＫｙ．ＥｆｆａｔＯｆ￣ｏｎｃＡＭＰｃｏｎａｌｓｏｆ￣ｎｅＰ￣Ｏｆ￣￣ｉｎＳＨＲａｎｄＷＫｙＩｎ￣ｎｇｃｏｎｒｍｈａｔｉｏｎｏｆＰＣＰ（１０－－＇－－１０－－＇ｍｏｌ／Ｌ）ｉｎｄｕｃｅａｄｏＳｅｄｒｐｅｎｄｅｎｔｉｎＣｒｅａｓｅｉｎｃＡＭＰｌｅＶｅｌｓｉｎｍｅｍｂｒａｎｅｐａ￣ｏｆｂｏｔｈＳＨＲａｎｄＷＫｙ．ＴｈｅＥＣ．ｖａｌｕｅＳｗｅｒｅ９．３ｘ１０－－７ｍｏｌ／ＬｆｏｒＷＫｙａｎｄ５．０ｘ１０－－６ｍｏｌ／ＬｆｏｒＳＨＲ．Ｔｈｅｓ￣ｔｏｒｙｅｆ
Radioimmunoassay was used to observe the effect of dynorphin (Dyn) and phencyclidine (PCP) on cAMP production in hypertensive rats (SHR). The results showed that: Dyn dose-dependently decreased the content of cAMP in the peripheral blood vessels of SHR and non-hypertensive rats (WKy) and inhibited the cAMP production system of SHR more than WKy (P <0.05); on the contrary, PCP The dose-dependent increase of cAMP content in peripheral blood vessels of SNR and WKy was less than that of WKy (P <0.05). These observations show: 1. Dyn and PCP exert an effect on SHR by inhibiting or activating the cyclic adenylate production system. 2. Peripheral arteries of SHR and WKy have different sensitivity to Dyn and PCP. P <0.01 vs. WKy. EffatOf ~ oncAMPconalsof ~ eP ~ Of ~ inSHRandWKyIn ~ ngrmhationofPCP (10 - ’- 10 -’ mol / L) induceadsorptioninCreaseincAMPleVelsinmembranepa ~ ofbothSHRandWKy. TheEC. valueSwere9.3x10--7mol / LforWKyand5.0x10--6mol / LforSHR. Thes ~ toryef