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作者在以色列对宋内志贺菌O特异性多糖与绿脓杆菌重组外蛋白A结合菌苗(Ssonnei-rEPA)与口服减毒大肠杆菌/2a型福氏志贺菌(EcSf2a-2)杂交菌苗的效果进行了现场考核.0.5ml S sonnei-rEPA含25μg多糖和75μg蛋白质,每次接种三角肌0.5ml.EcSf2a-2口服4次,于0、3、14和17天各口服1次,每次5～9×10~8 cfu.志愿者口服杂交菌苗或安慰剂前,服用碳酸氢钠.用四价脑膜炎球菌菌苗作对照剂接种三角肌.将1446名18～22岁以色列新兵随机分为7组(A～G组),除48人中途退出试验外,剩下1398人
In this paper, we studied the effects of Ssonnei-rEPA and EcSf2a-2 oral inoculation in mice on Shigella sonnei O-specific polysaccharides and Pseudomonas aeruginosa 0.5 ml S sonnei-rEPA contains 25 μg of polysaccharide and 75 μg of protein, 0.5 ml of deltoid inoculated each time.EcSf2a-2 is orally administered 4 times, orally once every 0, 3, 14 and 17 days, Each 5 ~ 9 × 10 ~ 8 cfu volunteers oral administration of oral vaccine or placebo prior to taking sodium bicarbonate quadrivalent meningococcal vaccine as a control agent inoculated deltoid 1446 18 to 22 years old Israel Recruits were randomly divided into 7 groups (A ~ G group), with the exception of 48 people quit the trial halfway, leaving 1398