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目的 观察小剂量米非司酮治疗子宫肌瘤的效果。方法 对25例妇科检查及B超诊断为子宫肌瘤患者用米非司酮每天12.5 mg,口服3个月,其中5例口服6个月。结果 用药3个月肌瘤缩小63.8％(P<0.01);用药6个月肌瘤缩小65.2％。与用药3个月比较,无显著差异(P>0.05)。所有患者治疗期间均闭经,停药后痛经、月经过多、阴道不规则流血症状明显改善。结论 小剂量米非司酮口服对年轻患者和有症状的子宫肌瘤(子宫<12周妊娠大)、围绝经期妇女是一种更为理想的保守治疗方法,以3个月为1疗程最合适。
Objective To observe the effect of low dose mifepristone on uterine fibroids. Methods 25 cases of gynecological examination and diagnosis of uterine fibroids by mifepristone 12.5 mg daily, orally for 3 months, of which 5 cases were orally for 6 months. Results The myoma of 3 months was reduced by 63.8% (P <0.01). The myoma of 6 months was reduced by 65.2%. Compared with the medication for 3 months, there was no significant difference (P> 0.05). All patients during amenorrhea, dysmenorrhea after menstruation, menorrhagia, irregular vaginal bleeding symptoms improved significantly. Conclusion Small doses of mifepristone orally for young patients and symptomatic uterine fibroids (uterine <12 weeks of pregnancy large), perimenopausal women is a more ideal conservative treatment to 3 months for a course of treatment is the most Suitable.