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二硫化四甲基秋兰姆(TMTD)是橡胶促进剂并广泛用作种子、水果、蔬菜的杀真菌剂。在鼠伤寒沙门氏菌试验中TMTD对TA_(100)及TA_(98)显示致突变活性,加入S_9致变活性增加,ICR小鼠骨髓微核试验表明,一次腹腔注入28mg/kg体重,多染红细胞微核率(MUPCE)显著增加,呈剂量-效应相关(r=0.939,P<0.01)。体外培养CHL,细胞的染色体畸变试验显示,染色体畸变率增至10—12%。 S.D大鼠致畸试验TMTD28,56,112mg/kg体重时,每窝活胎数明显减少,吸收胎,死胎率明显增加,并可见到四肢内翻,脑室扩人,心脏右移,肾移位等改变。研究表明,TMTD是一个致突变物及动物致畸物。
Tetramethylthiuram disulfide (TMTD) is a rubber accelerator and is widely used as a fungicide for seeds, fruits and vegetables. TMTD showed mutagenic activity on TA_ (100) and TA_ (98) in S. typhimurium test. The mutagenicity of S_9 was increased. Micronucleus test of ICR mouse bone marrow indicated that intraperitoneal injection of 28mg / kg body weight and multiple red blood cells The nuclear rate (MUPCE) increased significantly with a dose-effect correlation (r = 0.939, P <0.01). CHL cultured in vitro, chromosome aberration test showed that the rate of chromosome aberrations increased to 10-12%. SD rat teratogenicity test TMTD28,56,112mg / kg body weight, the number of live litter per litter significantly reduced, fetal and fetus increased significantly, and can see the limbs varicose veins, ventricular enlargement, right heart, renal transposition change. Research shows that TMTD is a mutagen and animal teratogen.