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目的:探讨常规体外受精(IVF)失败后,再次助孕采用卵胞浆内单精子显微注射(ICSl)技术进行受精的临床价值。方法:回顾性分析2007年1月~2009年7月由于常规体外受精(IVF)诊疗中卵子完全不受精或受精率≤30%,而在随后的助孕治疗中采取ICSI方法受精的39个病例(共48个周期,研究组)的ICSI治疗结局。对照组为同期因男方少弱畸形精子症或无精子症进行ICSI治疗的连续82个周期。结果:与前次IVF相比,经ICSI治疗后受精率从15.85%显著提高至81.77%(P<0.01);研究组患者平均年龄、不孕年限、成熟卵子数和正常受精率、冷冻率及临床妊娠率与对照组相比差异无统计学意义(P>0.05),但优质胚胎率差异有统计学意义(P<0.05)。结论:ICSI是常规WF周期受精失败后再助孕治疗的有效方法,能有效地克服受精障碍,提高受精率,明显改善妊娠结局。
Objective: To investigate the clinical value of fertilization after in vitro fertilization by intracytoplasmic sperm injection (ICSl) after conventional in vitro fertilization (IVF) fails. Methods: From January 2007 to July 2009, 39 cases of ICSI fertilization during subsequent IVF treatment due to complete ova fertilization or fertilization ≤30% in routine in vitro fertilization (IVF) were retrospectively analyzed. (Total 48 cycles, study group) ICSI treatment outcome. The control group consisted of 82 consecutive cycles of ICSI treatment for men with oligozoospermia or azoospermia during the same period. Results: Compared with the previous IVF, the fertilization rate increased significantly from 15.85% to 81.77% after ICSI treatment (P <0.01). The mean age, duration of infertility, number of mature eggs, normal fertilization rate, freezing rate, There was no significant difference in clinical pregnancy rate between the control group and the control group (P> 0.05), but there was a significant difference in the quality embryo rate (P <0.05). Conclusion: ICSI is an effective method of pregnancy-assisted pregnancy after the failure of routine WF cycle fertilization, which can effectively overcome the fertilization disorder, improve the fertilization rate and significantly improve the pregnancy outcome.