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建立阿霉素（ＡＤＲ）肾病大鼠模型。探讨ＡＤＲ肾病大鼠肾皮质匀浆及尿中溶血小板活化因子（ｌｙｓｏ－ＰＡＦ）的水平。结果显示ＡＤＲ肾病大鼠肾皮质匀浆及尿中ｌｙｓｏ－ｐＡＦ的含量明显增高；ＡＤＲ肾病大鼠的尿蛋白排泄与肾皮质匀浆、尿ｌｙｓｏ－ＰＡＦ的变化均呈明显的正相关，提示ＰＡＦ是ＡＤＲ肾病模型产生蛋白尿的重要介质，此研究进一步证实了ＰＡＦ在类似微小病变型肾病模型中的肾毒性作用。
To establish a rat model of adriamycin (ADR) nephropathy. To investigate the renal cortical homogenate and urinary lyso-PAF levels in ADR nephropathy rats. The results showed that the content of lyso-pAF in renal cortex homogenate and urine of rats with ADR nephropathy was significantly increased; excretion of urinary protein in ADR nephropathy rats was positively correlated with changes of renal cortical homogenate and urine lyso-PAF, suggesting that PAF Is an important mediator of proteinuria in the ADR nephropathy model and this study further confirms the nephrotoxic effect of PAF in a neoplastic minimal-nephropathy model.