老年人药物不良反应(adverse drug reactions,ADR)发生率高且程度严重,与ADR有关的死亡患者中,年龄>60岁者约占50%~([1])。老年患者ADR受累器官以胃肠道最为常见,占41.7%,其次是血液和肝胆系统,分别占16.7%和12.5%~([1-3])。药物性肝损伤(drug-induced liver injury,DILI)为严重ADR~([1,3])。老年人常因多种基础疾病(如冠状动脉性心脏病、高血压、糖尿病等)服用多种药物而增加DILI的发生风险。Marcum等~([4])报道年龄>70岁者平均每天服3.7种药物。日本学者报道~([5]),94.2%老年人每天至少服用1种药物,73.3%的老年人至少服用4种药物,如降压药、降脂药等。另外,老年 The incidence of adverse drug reactions (ADR) in the elderly is high and severe, with about 50% of patients aged> 60 years [1] who died of ADR-related deaths. ADR involvement in elderly patients with the most common gastrointestinal tract, accounting for 41.7%, followed by the blood and hepatobiliary system, accounting for 16.7% and 12.5% ​​~ ([1-3]). Drug-induced liver injury (DILI) is severe ADR ~ ([1,3]). The elderly often due to a variety of underlying diseases (such as coronary heart disease, hypertension, diabetes, etc.) taking a variety of drugs to increase the risk of DILI. Marcum et al. ([4]) reported an average of 3.7 drugs per day for those over 70 years of age. Japanese scholars reported ~ ([5]), 94.2% of the elderly take at least 1 drug daily, 73.3% of the elderly taking at least 4 drugs, such as antihypertensive drugs, lipid-lowering drugs. In addition, old age