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目的研究医院铜绿假单胞菌感染特点及其耐药性,为临床合理用药提供依据。方法采用回顾性调查方法,对某医院住院患者送检病原学标本中铜绿假单胞菌分离鉴定和药敏试验结果进行统计分析。结果从该医院住院患者送检的病原学标本中共检出铜绿假单胞菌258株,2011-2013年度检出株数依次为68株、82株和108株,主要分离自痰液标本,其次为脓液。临床分离的铜绿假单胞菌对临床常用16种抗菌药物普遍耐药,对多数头孢类抗菌药物和氨苄西林耐药率超过50%,仅对亚胺培南和美落培南耐药率较低,对氨曲南耐药率已超过30%。结论该医院临床分离的铜绿假单胞菌耐药情况严重,应根据药敏结果合理用药。
Objective To study the characteristics and drug resistance of Pseudomonas aeruginosa infection in hospitals and provide the basis for clinical rational drug use. Methods The retrospective investigation method was used to analyze the results of drug-susceptibility test and isolation and identification of Pseudomonas aeruginosa in etiological specimens of hospitalized patients. Results A total of 258 strains of Pseudomonas aeruginosa were detected in the etiological specimens of hospitalized patients. The number of detected strains in 2011-2013 was 68, 82 and 108, respectively, which were mainly isolated from sputum samples, followed by Pus. Pseudomonas aeruginosa clinically isolated commonly used in clinical 16 kinds of antimicrobials generally resistant to most cephalosporins antibacterials and ampicillin resistance rate of more than 50%, only imipenem and the lower the rate of resistance to the United States Pei Pei , The rate of resistance to aztreonam has exceeded 30%. Conclusion The clinical isolates of Pseudomonas aeruginosa isolated from the hospital are seriously drug-resistant and should be treated according to the susceptibility results.