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作者以前曾报告以硝苯吡啶(Nifedipine)改善严重的局部及全心缺血后血液动力学,生化,组织和超结构的改变。本文论述 Nifedipine 对心脏的影响,并与硝普钠和戊脉安(Verapamil)对比。这种对比是用开胸的狗进行的,阻断左前降支1或2小时(n=90),在选定的缺血与再灌注时间给药,实验狗行完全心肺转流在体温38℃下全心缺血1小时或者28℃下缺血2小时(n=38)。阻断左前降支的狗在局部缺血1小时或者
The authors previously reported that nifedipine improves hemodynamic, biochemical, tissue and ultrastructural changes following severe regional and global ischemia. This article discusses the effect of Nifedipine on the heart and compares it with sodium nitroprusside and Verapamil. This comparison was performed with a thoracotomy dog, blocking the left anterior descending artery for 1 or 2 hours (n = 90), dosing at the chosen time of ischemia and reperfusion, and the experimental dog undergoing complete cardiopulmonary bypass at body temperature 38 Ischemia at 1 ° C for 1 hour or at 28 ° C for 2 hours (n = 38). Dogs that block the left anterior descending branch are either ischemic for 1 hour or more