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目的探析在乳腺癌患者组织中P27和胰岛素生长因子I(IGF-I)的表达情况及临床价值。方法选取接受手术治疗的99例乳腺癌患者的蜡块组织,采用免疫组化SP法检测乳腺癌组织中IGF-I及P27的表达水平,分析P27、IGF-I表达与临床病理参数各自的关系以及其相互间的关系。结果 IGF-I表达与乳腺癌患者淋巴结转移相关,在有转移组织中的表达较高,无转移组织中的表达较低,组间差异有统计学意义(P<0.01);IGF-I表达与临床病理分期呈负相关(P<0.01),与TNM分级、病理分级及年龄均无关(P>0.05)。P27表达与乳腺癌患者有无淋巴结转移呈明显的负相关关系(P<0.01),与临床分期、病理分期、年龄、TNM分期、病理分级无显著相关性(P>0.05)。P27及IGF-I表达、淋巴结转移、临床分期均是乳腺癌患者预后独立危险因素(P<0.01),P27表达与IGF-I呈明显负相关关系(P<0.01)。结论在乳腺癌的进展过程中,IGF-I与P27可能扮演了重要的角色,同时可能是治疗乳腺癌的一个靶点。
Objective To investigate the expression of P27 and insulin-like growth factor-I (IGF-I) in breast cancer patients and its clinical value. Methods Totally 99 cases of breast cancer patients undergoing surgery were selected to study the expression of IGF-I and P27 in breast cancer tissues by immunohistochemical SP method. The relationship between the expression of P27 and IGF-I and clinicopathological parameters was analyzed And their relationship to each other. Results The expression of IGF-I was correlated with lymph node metastasis in breast cancer patients, with higher expression in metastatic tissues and lower in non-metastatic tissues with statistical significance (P <0.01) There was a negative correlation between clinical stage and clinical stage (P <0.01), but not with TNM grade, pathological grade and age (P> 0.05). There was a significant negative correlation between the expression of P27 and lymph node metastasis in patients with breast cancer (P <0.01). There was no significant correlation between P27 expression and clinical stage, pathological stage, age, TNM stage and pathological grade (P> 0.05). The expression of P27 and IGF-I, lymph node metastasis and clinical stage were all independent risk factors for prognosis of breast cancer patients (P <0.01). P27 expression was negatively correlated with IGF-I (P <0.01). Conclusion IGF-I and P27 may play an important role in the progression of breast cancer and may be a target for the treatment of breast cancer.