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朱砂(96%HgS)和雄黄(90%As4S4)与其它中药配伍应用于临床已有上千年历史。但由于朱砂含汞,雄黄含砷,其安全性近年来引起了越来越多的关注。一般认为把已知的金属毒物用于医药中不可取,但也有不同的意见认为朱砂和雄黄有长期用药历史,临床有效,其毒副作用可耐受。含朱砂、雄黄的中药是药还是毒?本文就含朱砂和雄黄的中成药的研究进展作一综述,并提出(1)以总砷和总汞为标准进行评价含朱砂、雄黄中药的安全性不妥,(2)朱砂和雄黄的用药量和用药时间决定其毒性反应,(3)朱砂和雄黄是中药复方中的有效成分之一,应作深入研究来决定其取舍。
Cinnabar (96% HgS) and realgar (90% As4S4) with other traditional Chinese medicine compatibility has been clinically used for thousands of years of history. But because of cinnabar mercury, realgar contains arsenic, its safety has attracted more and more attention in recent years. Generally believed that the known metal poison used in medicine undesirable, but there are different opinions that cinnabar and realgar have a long history of drug use, clinically effective, its toxic side effects can be tolerated. This article reviewed the research progress of proprietary Chinese medicines containing cinnabar and realgar, and proposed (1) to evaluate the safety of traditional Chinese medicines containing cinnabar and realgar with total arsenic and total mercury as the standard (2) cinnabar and realgar dosage and medication time to determine its toxicity, (c) cinnabar and realgar is one of the active ingredients in traditional Chinese medicine compound, should be studied in depth to decide its choice.