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目的研究2型糖尿病患者服用他汀类药物后的血脂及血液流变学状况变化,以降低心脑血管事件和脑血管意外的发生。方法检测南京农业大学社区135例2型糖尿病患者在服用他汀类药物前后的血脂及血液流变学指标,进行对比分析。结果 2型糖尿病患者在口服他汀类药物后对降低血脂中总胆固醇、三酰甘油、低密度脂蛋白和降低血液流变学中的全血高中低切、血浆黏度、压积、聚集指数差异有统计学意义(P<0.05),对血脂中的高密度脂蛋白和血液流变学中的血沉、刚性指数和变形指数的影响差异无统计学意义。结论 2型糖尿病患者常合并血脂、血液流变学改变,口服他汀类药物对降低血脂的作用较大,对血液流变学影响较缓慢,定期监测血脂以及血液流变学检查,是改善糖尿病预后以及预防糖尿病并发症的重要方式。
Objective To study the changes of blood lipids and blood rheology after taking statins in patients with type 2 diabetes to reduce the incidence of cardiovascular and cerebrovascular accidents. Methods The serum lipid and hemorheology indexes of 135 type 2 diabetic patients in Nanjing Agricultural University before and after taking statins were compared and analyzed. Results After oral administration of statins, patients with type 2 diabetes had lower blood lipid levels of total cholesterol, triglyceride, low density lipoprotein, and lower whole blood low and high blood flow in hemorheology. There were differences in plasma viscosity, (P <0.05). There was no significant difference in the effects of high density lipoprotein (LDL) on blood lipids, erythrocyte sedimentation rate (ER), erythrocyte sedimentation rate (RI) Conclusions Patients with type 2 diabetes mellitus often have dyslipidemia and hemorheology changes. Oral statins have a great effect on reducing blood fat and have a slow influence on hemorheology. Regular monitoring of blood lipids and blood rheology are two important factors in improving the prognosis of diabetes As well as an important way to prevent diabetic complications.