论文部分内容阅读
8条麻醉、开胸犬冠状动脉前降支急性停流90分钟后,用从股动脉引出的肝素抗凝自体血液,进行再灌注,观察冠状血管的组织形态学改变。与急性低流灌注相比,再灌注后的冠状血管受损范围扩大,程度加重。除内皮细胞脱落、变性,基底膜、内弹力膜断裂以及平滑肌的严重缺血性改变外,尚有明显的管壁血细胞浸润和血管周围出血。出血区心肌的退变、坏死亦加重。再灌注造成的冠状动脉形态学改变与冠状血管对某些血管活性物质的反应性改变密切相关。
Eight anesthesia and thoracotomy coronary artery anterior descending coronary artery 90 minutes after acute stop, using heparin derived from the femoral artery anticoagulation of autologous blood, reperfusion, observation of coronary vascular tissue morphological changes. Compared with the acute hypofluidic perfusion, the extent of coronary vasodilatation after reperfusion was expanded and worsened. In addition to endothelial cell shedding, degeneration, basement membrane, endometrial rupture, and severe ischemic changes of smooth muscle, there are obvious vascular wall blood cell infiltration and perivascular bleeding. Degeneration of the bleeding area of the myocardium, necrosis also increased. The morphological changes of coronary arteries caused by reperfusion are closely related to the changes of reactivity of some vasoactive substances in coronary vessels.