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目的了解西宁地区普通人群甲型H1N1流感病毒抗体水平,为科学评估和防控疫情提供参考依据。方法 2009年12月～2010年4月连续5个月,随机选择在医院就诊和血站献血的人员2132人,采集静脉血进行甲型H1H1流感血清抗体水平检测和分析。结果调查期间人群总体阳性率为38.18%,GMT水平为1︰24.35。疫苗接种人群的阳性率和GMT水平为89.71%和1︰51.75,明显高于未接种疫苗人群的33.57%和1︰22.76。非疫苗免疫人群中,6～24岁年龄组抗体阳性率和GMT水平最高(45.29%～50.25%,1︰27.8～1︰31.86),3岁以下、60岁及以上年龄组最低(21.62%～22.45%,1︰18.31～1︰19.84)。随着时间的推移未接种疫苗人群抗体的阳性率和GMT水平呈逐步上升的趋势。结论普通人群总体阳性率水平为41.02%,但幼儿和老年人保护性抗体比例仍然较低,提示该人群是今后甲型H1N1流感重点保护的对象。
Objective To understand the antibody level of Influenza A (H1N1) virus in the general population in Xining area and provide reference for scientific assessment and prevention and control of epidemic situation. Methods From December 2009 to April 2010 for 5 consecutive months, 2132 volunteers were randomly selected to receive blood donation and hospital blood donation, and venous blood samples were collected for the detection and analysis of serum antibody levels of type A H1N1 influenza. Results During the survey, the overall population positive rate was 38.18%, GMT level was 1: 24.35. The positive rates and GMT levels of the vaccinated population were 89.71% and 1︰51.75, which were significantly higher than those of the unvaccinated population of 33.57% and 1︰22.76 respectively. Among the non-vaccinated groups, the antibody positive rate and GMT level in the age group of 6-24 years old were the highest (45.29% -50.25%, 1︰27.8-1︰31.86), the lowest in the age group of 3 years old and the lowest in the age group of 60 years old and above (21.62% 22.45%, 1: 18.31 ~ 1: 19.84). Over time, the positive rate of non-vaccinated population antibody and GMT levels showed a gradual upward trend. Conclusion The overall prevalence rate of the general population is 41.02%, but the proportion of protective antibodies in infants and the elderly is still low, suggesting that this population is the key target of future H1N1 influenza protection.