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[目的]总结含西妥昔单抗(Cetuximab)方案治疗胃癌和食管癌的资料,探讨Cetuximab治疗胃癌或食管癌患者的初步疗效和安全性。[方法]收集2007年4月到2009年6月30日在中山大学肿瘤防治中心接受含Cetuximab方案治疗、经过客观疗效评价的5例胃癌和5例食管癌的资料,分析其有效性和毒副作用。[结果]10例患者共计完成65个Cetuximab治疗周期(中位周期数5.5)。单纯化疗的8例患者中,PR、SD、PD分别为3、2、3例,其中位TTP为3.5个月。2例同步放化疗者都为PR,其中位TTP为8个月。PR、SD、PD在胃癌组和食管癌组分别为1、2、2例和4、0、1例。胃癌组从诊断到随访结束的中位生存时间和从Cetuximab治疗到随访结束的中位生存时间分别是12个月和5个月,食管癌组分别是21个月和14个月。7例患者出现了毒副反应,与Cetuximab相关的毒副反应是皮疹和低镁血症。[结论]Cetuximab治疗胃癌和食管癌是比较安全的,但治疗效果有待进一步从大样本研究证实,本研究中食管癌的治疗效果好于胃癌很可能是由于病例选择引起的。
[Objective] To summarize the data of Cetuximab regimen in the treatment of gastric cancer and esophageal cancer, and to investigate the preliminary efficacy and safety of Cetuximab in the treatment of patients with gastric cancer or esophageal cancer. [Method] The data of 5 cases of gastric cancer and 5 cases of esophageal cancer receiving Cetuximab regimen from Sun Yat-sen University Cancer Center from April 2007 to June 30, 2009 were collected and analyzed for their efficacy and toxicity . [Results] A total of 65 cycles of Cetuximab were completed in 10 patients (median cycle 5.5). Of the 8 patients who underwent chemotherapy alone, the PR, SD, and PD were 3, 2 and 3, respectively, and the median TTP was 3.5 months. Two patients with concurrent radiochemotherapy were PR, with a median TTP of 8 months. PR, SD, PD in gastric cancer group and esophageal cancer group were 1, 2, 2 cases and 4, 0, 1 case. The median survival time from diagnosis to the end of follow-up and the median survival time from Cetuximab to the end of follow-up were 12 months and 5 months in gastric cancer patients and 21 and 14 months in esophageal cancer patients, respectively. Seven patients developed toxic side effects, and the toxic side effects associated with Cetuximab were rash and hypomagnesemia. [Conclusion] Cetuximab treatment of gastric cancer and esophageal cancer is relatively safe, but the treatment effect needs further study from a large sample confirmed that the treatment of esophageal cancer in this study is better than that of gastric cancer is likely to be caused due to case selection.