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目的：比较恩丹西酮和胃复安治疗大剂量顺铂诱发恶心、呕吐的疗效。方法：A组：26例，第1天用恩丹西酮24mg静滴化疗前30分钟或8mgiv缓推化疗前30分钟及化疗后2h。B组：22例，第1天用胃复安20mg肌注化疗前30分钟，地塞米松10mg静脉缓推化疗前15分钟。结果：恩丹西酮和胃复安对大剂量顺铂引起的即发和迟发恶心、呕吐的止吐率分别为88．5％、92．3％和50％、77．2％。结论：恩丹西酮对大剂量顺铂引起的即发恶心、呕吐优于胃复安。
Objective: To compare the efficacy of ondansetron and metoclopram in the treatment of high-dose cisplatin-induced nausea and vomiting. Methods: Group A: 26 cases, on the first day with ondansetron 24mg intravenous chemotherapy before 30 minutes or 8mgiv slowly push the 30 minutes before chemotherapy and chemotherapy after 2h. Group B: 22 cases, the first day with metoclopramide 20mg intramuscularly 30 minutes before chemotherapy, dexamethasone 10mg intravenous bolus 15 minutes before chemotherapy. Results: Ondansetron and metoclopram were 88.5%, 92.3% and 50%, 77.2% of the rate of nausea and vomiting caused by high dose cisplatin. Conclusion: Ondansetron is superior to metoclopramide in treating nausea and vomiting induced by high-dose cisplatin.