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强力霉素是治疗慢性支气管炎急性发作最常使用的抗菌素。它具有四环素族抗菌素的特点,同时有半衰期长(成人血清中半衰期为15～22小时),及在肾功能不全时仍能安全使用等优点。作者对5例慢性支气管炎病人应用常规剂量的强力霉素(第1日200毫克,第2～7日每日100毫克),测定其血清和支气管分泌物中的药物浓度。结果:口服负荷剂量200毫克后3小时血清浓度为5.4～3.46微克/毫升(平均4.33微克/毫升),23小时后下降为2.28～1.21微克/毫升)(平均1.71微克/毫升)。第2～7日,服药3、8及12小时后平均血清浓度分别为2.15、1.79和1.38微克/毫升。血清峰浓度在第1、2天显著高于第7天,此为负荷剂量的作用。痰中强力霉素浓度有很大的个体变异,范围很大(0.07～2.1微克/毫升,平均0.34
Doxycycline is the most commonly used antibiotic for the treatment of acute episodes of chronic bronchitis. It has the characteristics of tetracycline antibiotics, while having a long half-life (adult serum half-life of 15 to 22 hours), and in renal insufficiency can still be safe to use and so on. The authors used routine doses of doxycycline in five patients with chronic bronchitis (200 mg on day 1 and 100 mg daily on days 2 to 7) to determine their serum and bronchial secretions. Results: Serum concentrations of 5.4 to 3.46 μg / ml (mean 4.33 μg / ml at 3 h after oral loading of 200 mg) and 2.28-1.21 μg / ml after 23 h (average 1.71 μg / ml) were obtained. From the second to the seventh day, the mean serum concentrations after 3, 8 and 12 hours of treatment were 2.15, 1.79 and 1.38 μg / ml, respectively. Serum peak concentrations were significantly higher on day 1 and 2 than on day 7, which was a loading dose effect. There is a large individual variation in doxycycline concentration in sputum with a wide range (0.07-2.1 μg / mL, an average of 0.34