作者选择雄激素的17α-烷基化衍生物羟甲雄烷吡唑(stanozolol)用于治疗遗传性血管神经性水肿(HAE),对药物剂量和治疗反应性之间的相关性,副作用的发生率,内分泌应答,补体异常的改善以及治疗费用等做了全面的估价。 27名少壮年病人中女15人,男12人,另有23名有C1抑制物(C1 INH)蛋白水平降低的无关病人,所有病人治疗开始时第一次日剂量为2mg,以后因病人不同介于0.5-6mg之间,有的病人4或6mg/日,共2-10周。治疗期间每月检查一次血清中功能性 The authors chose the androgens of 17α-alkylated derivatives of stanozolol for the treatment of hereditary angioedema (HAE), the correlation between drug dosage and therapeutic reactivity, and the occurrence of side effects Rate, endocrine response, improvement of complement abnormalities and treatment costs made a comprehensive assessment. There were 15 males and 15 females with 12 males and 12 males. There were also 23 unrelated patients with reduced C1-INH protein levels. The first daily dose of 2 mg was given to all patients at the beginning of treatment, Between 0.5-6mg, some patients 4 or 6mg / day, a total of 2-10 weeks. Serum function was checked monthly for the duration of treatment