肝肾综合征(hepatorenal syndrome,HRS)是发生于严重肝病患者的自发性、功能性肾功能不全,常见于重症病毒性肝炎、失代偿性肝硬化或继发性晚期肝癌等肝衰竭时。当肝衰竭经治疗或自发改善后,此综合征可以逆转,其病理生理学还不完全明瞭,大部分病例对治疗无效,是当前肝衰竭的老大难问题之一。 HRS的第一次命名系在1932年,当时是 Hepatorenal syndrome (hepatorenal syndrome, HRS) is a spontaneous, functional renal insufficiency that occurs in patients with severe liver disease and commonly occurs in liver failure such as severe viral hepatitis, decompensated cirrhosis or secondary advanced liver cancer. When the liver failure after treatment or spontaneous improvement, the syndrome can be reversed, the pathophysiology is not yet fully understood, most cases of ineffective treatment, the current chronic liver failure is one of the problems. The first name for HRS was in 1932, when it was