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以短链取代基醚化β-环糊精能显著提高其水溶性,环糊精衍生物饱和溶解度的增加不受取代位置及取代程度影响。生成的环糊精醚也能将其它分子吸附于分子空隙形成包合物。有良好水溶性的β-环糊精醚可用作难溶性药物增溶剂。对环糊精醚包合物相态关系
The short-chain etherification of β-cyclodextrin can significantly improve its water solubility, the saturated solubility of cyclodextrin derivatives is not affected by the substitution position and degree of substitution. The resulting cyclodextrin ether can also adsorb other molecules in the molecular voids to form inclusion complexes. Beta-Cyclodextrins with good water solubility can be used as solubilizers for poorly soluble drugs. Cyclodextrin ether inclusion phase relationship