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目的探讨糖耐量低减患者血清抗AT1和抗α1受体自身抗体及与微量白蛋白尿的关系。方法以合成的AT1和α1受体多肽片段为抗原,应用酶联免疫吸附测定(ELISA)技术,检测IGT合并高血压患者171例,IGT不伴高血压患者101例及正常对照组40例人血清中抗G-蛋白偶联型AT1和α1受体自身抗体和微量白蛋白尿测定。结果①IGT合并高血压组抗AT1和抗α1受体自身抗体阳性率为35.7%(61/171)和29.8%(51/171),明显高于IGT不伴高血压组的20.8%(21/101)和18.8%(19/101)及正常对照组12.5%(5/40)和7.5%(3/40),比较具有统计学意义(P<0.05)。②IGT合并尿蛋白组(为IGT1组,UAE30-300mg/24h)血清抗AT1和抗α1受体自身抗体阳性率为71.8%(51/71)和69.1%(49/71),明显高于IGT不合并尿蛋白组(IGT2组,UAE<30mg/24h组)的15.4%(31/201)和10.4%(21/201)比较具有显著性统计学意义(P<0.01)。结论血清抗G-蛋白偶联型AT1和α1受体自身抗体阳性可能与IGT并高血压肾损害有关,抗AT1和抗α1受体自身抗体阳性率与微量白蛋白尿有关。
Objective To investigate the relationship between serum anti-AT1 and anti-α1 receptor autoantibodies and microalbuminuria in patients with impaired glucose tolerance. Methods The synthetic AT1 and α1 receptor peptide fragments were used as antigen. ELISA was used to detect 171 cases of patients with IGT complicated with hypertension, 101 cases of IGT without hypertension and 40 cases of normal control group Anti-G-protein coupled AT1 and α1 receptor autoantibodies and microalbuminuria assay. Results ① The positive rates of anti-AT1 and anti-α1 receptor autoantibodies in IGT patients with hypertension were 35.7% (61/171) and 29.8% (51/171), significantly higher than those in IGT patients without hypertension (20.8%, 21/101 ) And 18.8% (19/101) respectively, and 12.5% (5/40) and 7.5% (3/40) in normal control group (P <0.05). ② The positive rates of anti-AT1 and anti-α1 receptor autoantibodies in IGT1 group and UAE30-300mg / 24h group were 71.8% (51/71) and 69.1% (49/71), respectively, which were significantly higher than those in IGT group 15.4% (31/201) and 10.4% (21/201) of urine protein group (IGT2 group, UAE <30mg / 24h group) were statistically significant (P <0.01). Conclusion Serum anti-G-protein-coupled AT1 and α1 receptor autoantibodies may be related to IGT and renal hypertension, anti-AT1 and anti-α1 receptor autoantibody positive rate and microalbuminuria.