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首次用对映体选择性合成法制备了光学活性的益康唑和咪康唑。初步体外抗真菌活性试验结果表明,(R)-(—)-益康唑和(R)-(—)-咪康唑的抗真菌活性高于相应的(S)-异构体和外消旋体。
For the first time, optically active econazole and miconazole were prepared using enantioselective synthesis. The preliminary in vitro antifungal activity test results showed that the antifungal activities of (R) - (-) - econazole and (R) - (-) - miconazole were higher than those of the corresponding (S) Body