论文部分内容阅读
目的:考察圣肤霜乳膏中醋酸地塞米松透过皮肤的能力。方法:通过Hanson透皮吸收扩散仪,对圣肤霜乳膏进行体外透皮扩散实验,以反相高效液相色谱法测定接收池中地塞米松含量和皮肤局部载药量。结果:圣肤霜乳膏中醋酸地塞米松只有少量缓慢透过皮肤。结论:圣肤霜乳膏中的醋酸地塞米松发挥的是局部治疗作用,而不是透过皮肤起全身治疗作用。
OBJECTIVE: To investigate the ability of dexamethasone acetate to penetrate the skin in San cream cream. Methods: In vitro transdermal diffusion test was performed with Hanson transdermal absorption diffuser. The dexamethasone content in the receiving reservoir and the local dermal drug loading were determined by RP-HPLC. Results: Only a small amount of dexamethasone acetate gel slowly penetrates the skin. CONCLUSIONS: Dexamethasone Acetate in the Cream of Skin Cream acts as a topical treatment rather than as a systemic treatment through the skin.