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目的 :探讨胃癌患者血清透明质酸 (HA)、Ⅲ型前胶原肽 (PⅢP)、Ⅳ型胶原 (Ⅳ -C)、层粘连蛋白 (LN)含量及临床意义。方法 :采用放射免疫技术测定了 48例胃癌患者HA、PⅢP、Ⅳ -C、LN含量 ,并以消化性溃疡及正常健康组作为对照。结果 :胃癌组血清HA、PⅢP、Ⅳ -C、LN含量显著高于正常组 ,P <0 .0 1～ 0 .0 0 1,肝转移组高于肝未转移组 ,P <0 .0 5～ 0 .0 1,胃癌组HA、PⅢP高于消化性溃疡组 ,P <0 .0 5～ 0 .0 0 1。结论 :胃癌组血HA、PⅢP、Ⅳ-C、LN含量与肿瘤肝转移相关
Objective: To investigate the clinical significance of serum hyaluronic acid (HA), type Ⅲ procollagen peptide (P Ⅲ P), type Ⅳ collagen (Ⅳ -C) and laminin (LN) in patients with gastric cancer. Methods: The contents of HA, PⅢP, Ⅳ -C, LN in 48 patients with gastric cancer were measured by radioimmunoassay. Peptic ulcer and normal healthy group were taken as control. Results: The levels of serum HA, PⅢP, Ⅳ -C, LN in gastric cancer group were significantly higher than those in normal group, P <0.01-0.0001, and higher in liver metastasis group than in non-metastatic liver group, P <0.05 ~ 0. 01, HA and PⅢP in gastric cancer group were higher than those in peptic ulcer group, P <0.05-0.010. Conclusion: The contents of HA, PⅢP, Ⅳ-C and LN in gastric cancer group are correlated with liver metastasis