本文报道了喜树碱前体多相脂质体(A-CPT-PL)小鼠体内的组织分布研究结果。静注给药后,A-CPT-PL主要分布于肺,给药后24h内组织中药物浓度时间曲线下面积AUC_0~(24)依肺、肝、肠、肾、脾、血、胃、心、骨、脑的顺序递减,这种分布特征是脂质体运载药物的结果;A-CPT-PL的组织分布是剂量依赖性的。口服给药后,大部分药物仍然保留在消化道系统。 This paper reports the tissue distribution of camptothecin precursor multiphasic liposomes (A-CPT-PL) in vivo. After intravenous administration, A-CPT-PL mainly distributed in the lungs. Within 24 hours after administration, the area under the curve of the drug concentration in the tissues was AUC 0 ~ (24). According to the lung, liver, intestine, kidney, spleen, blood, stomach and heart , Bone, brain decline in order, this distribution is the result of drug delivery of liposomes; tissue distribution of A-CPT-PL is dose-dependent. After oral administration, most of the drug remains in the digestive system.