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目的探讨采用三维适形放疗联合紫杉醇+顺铂(TP)方案治疗食管癌放疗后复发患者的临床疗效。方法选取2011年6月至2013年6月间北华大学附属医院收治的98例食管癌放疗后复发患者,根据治疗方式的不同分为观察组和对照组,每组各49例。观察组患者行三维适形放疗联合TP方案治疗,对照组患者行单纯三维适形放疗治疗,比较两组患者的临床疗效。结果观察组患者的治疗总有效率明显高于对照组(P<0.05),观察组患者的2年生存率明显高于对照组(P<0.05),两组患者的不良反应发生情况比较,差异有统计学意义(P<0.05)。结论采用三维适形放疗配合TP化疗治疗食管癌放疗后复发患者,可提高患者近期疗效及生存率,对于无化疗禁忌证的患者可考虑采用同步化疗。
Objective To investigate the clinical efficacy of three-dimensional conformal radiotherapy combined with paclitaxel + cisplatin (TP) in the treatment of esophageal cancer recurrence after radiotherapy. Methods A total of 98 patients with esophageal cancer recurrence after radiotherapy were selected from Affiliated Hospital of Beihua University from June 2011 to June 2013. According to the different treatment methods, the patients were divided into observation group and control group, 49 cases in each group. Patients in the observation group underwent three-dimensional conformal radiotherapy combined with TP regimen. Patients in the control group received simple three-dimensional conformal radiotherapy and compared the clinical efficacy of the two groups. Results The total effective rate of observation group was significantly higher than that of control group (P <0.05). The 2-year survival rate of observation group was significantly higher than that of control group (P <0.05). There was significant difference in adverse reactions between two groups There was statistical significance (P <0.05). Conclusion Three-dimensional conformal radiotherapy combined with TP chemotherapy for esophageal cancer recurrence patients after radiotherapy can improve the short-term efficacy and survival of patients, for patients without chemotherapy contraindications may consider using synchronous chemotherapy.