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引言目前抗胃酸分泌药及细胞保护药的研究进展虽然很快,但抗酸剂仍是治疗许多胃病的良药。抗酸剂的胃酸中和容量是其发挥药效的主要因素。抗酸剂的药效还受到胃排空、胃酸分泌速度等生理因素的影响。抗酸剂通常为非处方药物,适应症较广,可用于治疗由于暴食、嗜酒、消化不良和胃灼热等引起的不适。传统的抗酸剂为弱碱性化合物,其中包括碳酸氢钠、碳酸钙、碳酸镁、氢氧化镁、氧化镁、氢氧化铝、磷酸铝、三硅酸镁等。其它诸如海藻酸、聚二甲基硅烷(dimethicone)、抗
INTRODUCTION At present, the research progress on anti-gastric acid secreting drugs and cytoprotective drugs is rapid, antacid is still a good medicine for treating many stomach diseases. Antacid gastric acid neutralization capacity is the main factor in its efficacy. Antacid efficacy is also affected by gastric emptying, gastric acid secretion and other physiological factors. Antacids are usually over-the-counter medications and have a wide range of indications that can be used to treat discomfort caused by binge eating, alcohol abuse, indigestion and heartburn. Conventional antacids are weakly alkaline compounds, including sodium bicarbonate, calcium carbonate, magnesium carbonate, magnesium hydroxide, magnesium oxide, aluminum hydroxide, aluminum phosphate, magnesium trisilicate and the like. Other such as alginic acid, dimethicone, anti