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目的探讨老年2型糖尿病患者血清糖类抗原19-9(CA19-9)水平与血糖的关系。方法 150例老年2型糖尿病患者,根据糖化血红蛋白水平分为三组:血糖控制良好组(A组,47例,糖化血红蛋白<6.5%)、血糖控制尚可组(B组,49例,糖化血红蛋白6.5%-7.5%)、血糖控制差组(C组,54例,糖化血红蛋白>7.5%)。另选糖耐量正常者100例为对照组(D组)。检测四组糖化血红蛋白和血清CA19-9水平。结果C组血清CA19-9水平明显高于A组、B组、D组[(19.26±7.92)U/ml vs.(11.57±5.83)U/ml、(13.52±6.57)U/ml、(11.42±5.36)U/ml](P<0.05),而A组、B组、D组血清CA19-9水平比较差异无统计学意义。结论老年2型糖尿病患者CA19-9水平增高和长期血糖控制差有密切关系。
Objective To investigate the relationship between serum level of carbohydrate antigen 19-9 (CA19-9) and blood glucose in elderly patients with type 2 diabetes mellitus. Methods One hundred and fifty elderly patients with type 2 diabetes mellitus were divided into three groups according to the level of HbA1c: blood glucose control group (group A, n = 47, HbA1c <6.5%), blood glucose control group (group B, n = 49, glycated hemoglobin 6.5% -7.5%), poor glycemic control group (C group, 54 cases, glycosylated hemoglobin> 7.5%). Another 100 cases of normal glucose tolerance as a control group (D group). Four groups of glycated hemoglobin and serum CA19-9 levels were detected. Results The level of serum CA19-9 in group C was significantly higher than that in group A, B and D [(19.26 ± 7.92) U / ml vs. (11.57 ± 5.83) U / ml, (13.52 ± 6.57) U / ml, ± 5.36) U / ml] (P <0.05), while there was no significant difference in serum CA19-9 between groups A, B and D. Conclusion There is a close relationship between CA19-9 level and long-term glycemic control in elderly patients with type 2 diabetes mellitus.