本文报道一种少见类型的低增生性急性白血病。其诊断根据为:1.多次多部位骨髓穿刺有核细胞增生低下;2.骨髓中原始加早(幼)细胞在30%以上,且有白血病细胞形态学改变;3.骨髓病理活检造血细胞减少。目前,该病尚无满意治疗方法,国内外在近10多年的报道中疗效均较差。我们对5例HAL应用逐步增强化疗法,均取得了完缓解(CR),CR期最长已达15个月,目前仍处于CR中,疗效满意。本文着重讨论了逐步增强化疗法的原则、方法及临床应用价值。 This article reports a rare type of hypo-proliferative acute leukemia. The diagnosis is based on: 1. Multiple bone marrow puncture multiple nuclear hyperplasia; 2. Bone marrow primitive plus early (young) cells in more than 30%, and leukemia cell morphology changes; 3. Bone marrow biopsy hematopoietic cells cut back. At present, there is no satisfactory treatment for this disease, and the curative effects in the reports of over 10 years both at home and abroad are poor. We have achieved complete remission (CR) in 5 cases of HAL, and the longest CR period has reached 15 months, which is still in CR. The curative effect is satisfactory. This article focuses on the principles, methods and clinical value of escalating chemotherapy.