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目的研究转化生长因子-β1(TGF-β1)和整合素β3(Integrinβ3)在妊娠期高血压疾病患者胎盘组织中的表达,并探讨其与妊娠期高血压疾病发病的关系。方法采用免疫组织化学染色(SP法)分别检测Integrinβ3、TGF-β1在12例妊娠期高血压疾病患者及13例正常妊娠者胎盘组织中的表达。结果妊娠期高血压疾病组胎盘Integrinβ3表达明显高于正常妊娠组(P<0.01)。妊娠期高血压疾病组胎盘TGF-β1表达亦明显高于正常妊娠组(P<0.01)。结论与正常妊娠组比较妊娠期期高血压疾病患者胎盘组织integrinβ3、TGF-β1的表达明均显增高。表明integrinβ3、TGF-β1可能参与妊娠期高血压疾病的发生和发展。
Objective To investigate the expression of transforming growth factor-β1 (TGF-β1) and integrin β3 in placenta of patients with gestational hypertension (Hypertension) and to explore its relationship with the development of hypertensive disorder complicating pregnancy. Methods Immunohistochemical staining (SP method) was used to detect the expression of Integrinβ3 and TGF-β1 in placenta of 12 cases of hypertensive disorder complicating pregnancy and 13 cases of normal pregnancy. Results The placental expression of Integrinβ3 in gestational hypertension group was significantly higher than that in normal pregnancy group (P <0.01). The placental expression of TGF-β1 in gestational hypertension group was also significantly higher than that in normal pregnancy group (P <0.01). Conclusion Compared with the normal pregnancy group, the expression of integrinβ3 and TGF-β1 in the placenta of patients with hypertensive disorders in pregnancy are significantly increased. The results showed that integrinβ3 and TGF-β1 may be involved in the occurrence and development of hypertensive disorder complicating pregnancy.