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目的研究氟康唑片(抗真菌药)在中国维吾尔族和汉族健康人体内的药代动力学。方法10名维吾尔族和10名汉族健康受试者,口服氟康唑片200 mg,用高效液相色谱法测定血浆中氟康唑浓度,用DAS Ver 2.0软件计算药代动力学参数。结果氟康唑片在维吾尔族和汉族健康受试者的主要药代动力学参数:Cmax分别为(4.99±1.05)、(4.91±0.67)mg·L-1,tmax分别为(2.30±0.95)、(1.90±0.91)h,t1/2分别为(30.47±6.27)、(31.41±2.90)h,AUC0-96分别为(176.26±22.08)、(190.08±33.17)mg·h·L-1,AUC0-∞分别为(199.93±30.18)、(218.18±40.43)mg·h·L-1。结论维吾尔族和汉族受试者单剂量口服氟康唑片药代动力学参数的差异无统计学意义。
Objective To study the pharmacokinetics of fluconazole tablets (antifungal agents) in healthy Uygur and Han Chinese. Methods Ten Uygur and 10 Han healthy subjects were given oral fluconazole 200 mg. The concentration of fluconazole in plasma was determined by HPLC, and the pharmacokinetic parameters were calculated by DAS Ver 2.0 software. Results The main pharmacokinetic parameters of fluconazole tablets were (4.99 ± 1.05) and (4.91 ± 0.67) mg · L-1, respectively in healthy Uygur and Han healthy subjects. The tmax values were (2.30 ± 0.95) , (1.90 ± 0.91) h and t1 / 2 were (30.47 ± 6.27) and (31.41 ± 2.90) h, respectively. The AUC0-96 values were (176.26 ± 22.08) and (190.08 ± 33.17) mg · h · L- AUC0-∞ were (199.93 ± 30.18) and (218.18 ± 40.43) mg · h · L-1, respectively. Conclusion There was no significant difference in the pharmacokinetic parameters of fluconazole tablets between Uygur and Han subjects.