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肝脏是合成各种凝血因子的主要脏器,其中Ⅱ、Ⅶ、Ⅸ、Ⅹ因子的合成,需要维生素K参与,属维生素K依赖因子。在严重肝脏疾病,如中毒性肝炎、重症肝炎、晚期肝硬化等肝实质细胞损害时,Ⅶ因子减少最显著,继之Ⅱ、Ⅹ因子降低,最后Ⅸ因子也受影响。肝细胞损害基本与这4种凝血因子减少程度呈正相关。肝促凝血活酶试验(hepatoplastin test,HPT)可反映肝脏的储备功能,还能精确反映肝脏疾病所造成的Ⅱ、Ⅶ、Ⅹ凝血因子的合成障碍。对急性肝功能衰竭的早期诊断、慢性肝损害的严重程度和维生素K
The liver is the major organ for the synthesis of various clotting factors. Among them, the synthesis of Ⅱ, Ⅶ, Ⅸ and Ⅹ factors requires the participation of vitamin K, which is a vitamin K-dependent factor. In severe liver disease, such as toxic hepatitis, severe hepatitis, advanced liver cirrhosis and other liver parenchymal cells, the most significant reduction in factor â ... ¡, followed by â ... ¡, â ... ¡factor decreased, and finally â ... £ factor is also affected. Liver cell damage and the four basic reduction in coagulation factors was positively correlated. Hepato-thrombosis test (HPT) can reflect the reserve function of the liver, but also can accurately reflect the hepatic diseases caused by Ⅱ, Ⅶ, Ⅹ coagulation factors synthesis obstacles. Early diagnosis of acute liver failure, severity of chronic liver damage, and vitamin K