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本组隐球菌性脑膜炎的治疗，采用两性霉素B十5一氟胞嘧啶方案者优于氟康唑十5一氟胞嘧啶方案，主张氟康唑用于隐球菌性脑膜炎治愈后巩固治疗及年老体弱不能耐受两性霉素B者。两性霉素B＋5一氟胞嘧啶治疗痊愈病例平均疗程6个月，两性霉素B静滴总量平均6．3g，最大可达8．5g，鞘内注射量平均26．4ms最大43．5mg。痊愈标准应以临床症状消失，连续三次（每次间隔7天）脑脊液涂片未找到隐球菌为准，而隐球菌培养阴性仅作参考指标。两性霉素B及氟康唑均可致药物性肝功能衰竭。
This group of cryptococcal meningitis treatment, the use of amphotericin B 十 5-fluorocytosine program is superior to fluconazole ten 5-fluorocytosine program, advocate fluconazole for cryptococcal meningitis cured after the consolidation Treatment and frail elderly can not tolerate amphotericin B were. Amphotericin B +5 a flucytosine treatment of patients with an average of 6 months treatment, amphotericin B intravenous infusion of an average of 6.3g, up to 8.5g, intrathecal injection average 26.4ms maximum 43.5mg. Clinical criteria should be cured disappeared, three times in a row (each interval of 7 days) CSF was not found to prevail, and cryptococcal culture negative only as a reference index. Amphotericin B and fluconazole can cause drug-induced liver failure.