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本文对23例联合用广谱抗生素的老年前期及老年患者发生腹泻后,进行了肠菌群分析,部分做了难辨梭菌的培养。结果表明,全部被检患者应用广谱抗生素后都发生腹泻,应用抗生素种类繁多,其中以氨苄加庆大或先锋加庆大最多。取患者新鲜便作肠菌群分析,6例曾进行纤维结肠镜检查,其中2例肠粘膜有小片状伪膜附着。在使用大量、多种抗生素后,最短在半天内,大多在2周内即发生腹泻,菌群中肠杆菌、拟杆菌、双歧杆菌、乳杆菌,肠球菌、葡萄球菌、酵母菌、小梭菌及真杆菌有显著的差异,均明显低于正常,6/15例难辨梭菌为阳性,检出率40％。治疗先停用抗生素加强支持疗法或用健康人粪便滤液灌肠,15例停止腹泻,2例使用万古霉素才停止。
In this paper, after 23 cases of diarrhea in elderly pre-senile and elderly patients combined with broad-spectrum antibiotics, intestinal flora analysis was carried out, and some Clostridium difficile strains were cultured. The results showed that all patients were detected after the application of broad-spectrum antibiotics are diarrhea, a wide range of applications of antibiotics, of which ampicillin Qingda or pioneer plus Qingda up. Fresh patients were taken for intestinal flora analysis, 6 cases had colonoscopy, including 2 cases of small intestinal mucosa attached to the pseudomembranous. In the use of a large number of, a variety of antibiotics, the shortest in half a day, most of the diarrhea occurs within 2 weeks, the group of Enterobacteriaceae, Bacteroides, Bifidobacterium, Lactobacillus, Enterococcus, Staphylococcus, yeast, shuttle There were significant differences between bacteria and eubacteria, which were all obviously lower than normal. 6/15 Clostridium difficile was positive, the detection rate was 40%. Treatment stopped using antibiotics to strengthen supportive therapy or enema with healthy human excrement filtrate, 15 cases stopped diarrhea, 2 cases stopped using vancomycin.