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目的：探讨他巴唑与强的松合用对Ｇｒａｖｅｓ病（ＧＤ）甲状腺功能及自身抗体的影响。方法：选择初诊的ＧＤ６７例，随机分成两组。治疗组给予他巴唑和强的松各 １５ ｍｇ／ｄ，对照组他巴唑 １５ ｍｇ／ｄ，均于上午８时顿服。结果：治疗４周及８周后Ｔ３、Ｔ４同时正常者：治疗组分别为２７例和３５例（７７．１４％、１００％）；对照组分别为１５例和２４例（４７％、７５％），差异显著（Ｘ２＝６．５４７，Ｐ＜０．０２５； Ｘ２＝９．９３６，Ｐ＜０．００５）。Ｔ３、Ｔ４恢复正常所需时间治疗组为４．９１±１．７０周；对照组为７．０１±３．３２周，两组比较差异显著（Ｐ＜０．００５）。治疗３个月及１２个月后，ＴＧＡｂ、ＴＭＡｂ及ＴＲＡｂ抑制率明显高于对照组（ Ｐ均＜ ０． ０５）。结论：他巴唑与强的松联合应用疗效优于单用他巴唑。
Objective: To investigate the effect of methimazole combined with prednisone on thyroid function and autoantibodies in Graves’ disease (GD). Methods: The newly diagnosed GD67 cases were randomly divided into two groups. The treatment group was given metoprolol and prednisone 15 mg / d, the control group methimazole 15 mg / d, both at 8:00 am Dayton clothing. Results: After treatment for 4 weeks and 8 weeks, both T3 and T4 were normal at the same time: the treatment group were 27 cases and 35 cases (77.14%, 100%) respectively; the control group were 15 cases and 24 cases (47%, 75% ), Significant difference (X2 = 6.547, P <0.025; X2 = 9.936, P <0.005). The time required for T3 and T4 to return to normal was 4.91 ± 1.70 weeks in the treatment group and 7.01 ± 3.32 weeks in the control group, with significant difference between the two groups (P <0.005). The inhibition rates of TGAb, TMAb and TRAb at 3 months and 12 months after treatment were significantly higher than those in the control group (all P <0.05). Conclusion: The combination of methimazole and prednisone is better than methimazole alone.