肾病综合征患者使用强的松或强的松龙后尿蛋白会增多。为了弄清其机制,作者研究了9例(男7例,女2例)肾病综合征患者在静脉输注强的松龙(125～150mg/次)后短期内尿蛋白的变化。 9例患者的平均年龄为53±6岁,内生肌酐清除率为104±30ml/min,尿蛋白量为7.7±3.0g。用强的松龙后五小时内,所有患者的平均总尿蛋白排泄量从先前的4.89±0.59mg/min增加到9.09±0.99mg/min(P<0.01)。肾小球滤过率(菊粉清除率)、有效肾血流量(对氨基马尿酸盐清除率)和滤过分数无显著变化。尿中白蛋白)IgG和 Patients with nephrotic syndrome use prednisone or prednisolone will increase urinary protein. In order to clarify its mechanism, the authors studied the short-term urinary protein changes in 9 patients (7 males and 2 females) with nephrotic syndrome after intravenous infusion of prednisolone (125-150 mg / dose). The mean age of 9 patients was 53 ± 6 years, the creatinine clearance rate was 104 ± 30 ml / min, and the amount of urinary protein was 7.7 ± 3.0 g. Within five hours of using prednisolone, the mean total urinary protein excretion of all patients increased from 4.89 ± 0.59 mg / min to 9.09 ± 0.99 mg / min (P <0.01). There was no significant change in glomerular filtration rate (inulin clearance), effective renal blood flow (p-aminomalanine clearance), and filtration fraction. Urine albumin) IgG and