以菲律宾马尼拉Sam Lazaro医院收治的经厚、薄血片确诊的100例恶性疟病例为对象。于氯喹治疗前,取血用体外法测定抗性,取尿测定磺胺类和4-氨基喹啉化合物。按照WHO规定,分别在5.7pmol氯喹、4p-mol氨酚喹、64pmol奎宁和16pmol甲氟喹浓度中,裂殖子仍繁殖者,列为抗性。体内法以服用25mg/kg氯喹基质,连续3天, One hundred cases of falciparum malaria confirmed by thick and thin films were treated at Sam Lazaro Hospital, Manila, Philippines. Before chloroquine treatment, blood samples were tested for resistance by in vitro methods and urine was tested for sulfonamides and 4-aminoquinoline compounds. According to WHO regulations, merozoites are still breeders at 5.7 pmol chloroquine, 4 p-mol paraquat, 64 pmol quinine and 16 pmol mefloquine respectively, which is classified as resistance. In vivo method to take 25mg / kg chloroquine matrix, for 3 days,