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Objective: To detect the expression of GAS7 in osteosarcoma and discuss its significance. Methods: Immuno- histochemistry SABC method was applied to detect GAS7 expression in specimens of 54 osteosarcoma and 15 osteochon- droma cases. Results: The positive expression rate of GAS7 was 74.7% (40/54) in the group of osteosarcoma and 0% (0/15) in the group of osteochondroma. There was a significant difference in the comparison of GAS expression in these two groups (P < 0.05). GAS7 was higher expressed in the samples which complicated with relapse or pulmonary metastasis than the control group (P < 0.05). There was no significant association between GAS7 expression and the size of tumor, the gender or the age of the patients (P > 0.05). Conclusion: The hyper-expression of GAS7 may play an important role in the initiation and development of human osteosarcoma.
Methods: Immunohistochemistry SABC method was applied to detect GAS7 expression in specimens of 54 osteosarcoma and 15 osteochon-droma cases. Results: The positive expression rate of GAS7 was 74.7 % (40/54) in the group of osteosarcoma and 0% (0/15) in the group of osteochondroma. There was a significant difference in the comparison of GAS expression in these two groups (P <0.05). GAS7 was higher expressed in the samples which complicated with relapse or pulmonary metastasis than the control group (P <0.05). There was no significant association between GAS7 expression and the size of tumor, the gender or the age of the patients (P> 0.05). Conclusion: The hyper-expression of GAS7 may play an important role in the initiation and development of human osteosarcoma.