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目的:研究影响大鼠心梗模型存活率的因素。方法:采用正交实验,以不同插管方式(经口插管,切开插管)、麻药(水合氯醛,乌拉坦)、是否采用利多卡因设计三因素两水平方案,观察大鼠插管后心率、术中死亡率、围手术期死亡率、总死亡率、室性心律失常放生率、发生室性心律失常大鼠死亡率、术后感染率。结果:插管方式是插管后心率、术中死亡率、总死亡率的主要因素,是否采用利多卡因是围手术期死亡的主要因素,不同麻醉剂是大鼠室性心律失常发生率的主要因素。发生室性心律失常大鼠与心率失常后死亡率有明显的相关性。水合氯醛麻醉与是否采用利多卡因是影响大鼠围手术期死亡率的主要因素。大鼠术后感染与不同插管方式,麻醉剂、利多卡因无关。结论:对于初作者采用气管切开插管、水合氯醛联合利多卡因是可以采用的试验方案。
Objective: To study the factors affecting the survival rate of rat myocardial infarction model. Methods: Orthogonal experiments were conducted with different intubation methods (oral intubation, intubation), anesthetics (chloral hydrate and urethane), and whether or not lidocaine was used to design a three-factor and two-level regimen. Tube heart rate, intraoperative mortality, perioperative mortality, total mortality, ventricular arrhythmia release rate, the incidence of ventricular arrhythmia rat mortality, postoperative infection rate. Results: Intubation was the main factor of heart rate, intraoperative mortality and total mortality after intubation. Whether lidocaine was used or not was the major cause of perioperative death. Different anesthetics were the main cause of ventricular arrhythmia in rats factor. The occurrence of ventricular arrhythmia in rats with arrhythmia mortality was significantly correlated. Chloral hydrate anesthesia with or without lidocaine is the main factor affecting the perioperative mortality in rats. Postoperative infection in rats with different intubation, anesthetics, lidocaine nothing to do. CONCLUSIONS: For tracheostomy with intratracheal intubation, chloral hydrate plus lidocaine is a viable protocol.