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目的:评价在手足口病的治疗中共同使用蓝芩口服液和利巴韦林气雾剂的临床作用。方法:选取2014年8月—2015年6月在医院接受诊断和治疗88例手足口病患者,按照随机数字表法分为两组,对照组给予单一利巴韦林气雾剂治疗,实验组给予蓝芩口服液联合利巴韦林气雾剂治疗。对比两组患者临床症状好转时间、病毒转阴情况、临床综合作用效果和不良反应发生情况。结果:实验组患者的退热、疱疹结痂、疱疹消退、初次进食时间与对照组患者的相比明显缩短;实验组患者的EV71病毒的转阴率(92.31%)、总肠道病毒转阴率(92.68%)明显高于对照组患者的EV71病毒的转阴率(61.54%)、总肠道病毒转阴率(65.85%);实验组患者总有效率(90.91%)与对照组的(70.45%)存在明显差异,差异均有统计学意义(P<0.05)。实验组患者不良反应发生率6.82%与对照组的9.09%相比,差异无统计学意义(P>0.05)。结论:蓝芩口服液联合利巴韦林气雾剂治疗手足口病临床效果显著,加快患者临床症状改善的程度,提高临床病毒的转阴率。
OBJECTIVE: To evaluate the clinical utility of the combination of Lanqin oral and ribavirin aerosols in the treatment of hand-foot-mouth disease. Methods: Eighty-eight patients with hand-foot-mouth disease were diagnosed and treated in the hospital from August 2014 to June 2015. The patients were divided into two groups according to the random number table. The control group was treated with a single ribavirin aerosol. The experimental group Give Lanqin oral solution combined with ribavirin aerosol treatment. Comparison of two groups of patients with clinical symptoms improved time, the virus negative situation, the clinical effect of combined effects and adverse reactions. Results: In the experimental group, fever, scab and herpes subsided in the experimental group, and the time of first feeding was significantly shorter than that in the control group. In the experimental group, the rate of negative conversion of EV71 (92.31%), total enterovirus negative (92.68%) was significantly higher than that of the control group (61.54%) and total enterovirus negative rate (65.85%). The total effective rate (90.91%) in the experimental group was significantly higher than that of the control group 70.45%), there were significant differences (all P <0.05). The incidence of adverse reactions in the experimental group was 6.82% compared with 9.09% in the control group, the difference was not statistically significant (P> 0.05). Conclusion: The clinical effect of Lanqin oral liquid combined with ribavirin aerosol in the treatment of hand, foot and mouth disease is significant, which can speed up the improvement of clinical symptoms and increase the negative rate of clinical virus.