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探讨α1-微球蛋白（α1—M）是为测定肾功能的特异指标及使用不同血液净化方法清除α1—M效果的比较。采用检测40例正常人与60例肾病和尿毒症患者的血清α1—M水平及不同血液净化方法对比，治疗前后的α1—M与β2—微球蛋白（β2—M）、肌酐（Scr）、尿素氮（BuN）的水平。结果是肾病患者和尿毒症患者α1—M水平增高，尿毒症患者各组的α1—M增高明显，并与β2—M、Scr、BuN的增高呈正相关。血液滤过（HF）和血液透析滤过（HDF）在治疗后α1—M有明显下降．提示肾功能测定中，α1—M测定是最灵敏和最有特异性。HF及HDF清除α1—M效果最佳。
To investigate α1-microglobulin (α1-M) is a specific index for the determination of renal function and the use of different methods of blood purification α1-M effect of the comparison. The levels of α1-M and β2-microglobulin (β2-M), creatinine (Scr) and creatinine in serum of 40 patients with nephropathy and uremia were measured before and after treatment. The level of urea nitrogen (BuN). As a result, the level of α1-M in patients with nephropathy and uremia increased, and the levels of α1-M increased significantly in each group of uremia patients, which was positively correlated with the increase of β2-M, Scr and BuN. Hemofiltration (HF) and hemodiafiltration (HDF) significantly decreased α1-M after treatment. Prompt renal function test, α1-M assay is the most sensitive and most specific. HF and HDF removal α1-M effect best.