目的观察雷公藤多甙和米非司酮治疗子宫肌瘤的临床疗效。方法子宫肌瘤患者62例,随机分为2组,分别给予米非司酮和雷公藤多甙治疗3个月;观察其临床疗效、子宫及子宫肌瘤体积的变化和不良反应。结果两组临床症状均得到明显改善;米非司酮组和雷公藤多甙组的子宫体积分别减小18.1%、41.5%,而子宫肌瘤体积分别缩小36.4%、59.6%;血中孕酮和雌二醇的含量分别比治疗前降低53.6%、56.5%和41.6%、41.8%,而卵泡刺激素和黄体生成素比治疗前分别增加119.7%、134.6%和118.6%、113.2%。结论雷公藤多甙和米非司酮均为治疗子宫肌瘤的有效药物。 Objective To observe the clinical efficacy of tripterygium glycosides and mifepristone in the treatment of uterine fibroids. Methods Totally 62 patients with uterine fibroids were randomly divided into 2 groups and treated with mifepristone and tripterygium glycosides for 3 months respectively. The clinical curative effect, changes of uterine and uterine fibroids volume and adverse reactions were observed. Results The clinical symptoms of both groups were significantly improved; the uterine volume of the mifepristone group and the tripterygium glycosides group decreased by 18.1% and 41.5%, while the uterine fibroids volume decreased by 36.4% and 59.6% respectively; And estradiol levels decreased by 53.6%, 56.5% and 41.6%, 41.8% respectively compared with before treatment, while the levels of follicle-stimulating hormone and luteinizing hormone increased by 119.7%, 134.6% and 118.6% and 113.2% respectively compared with those before treatment. Conclusion Tripterygium glycosides and mifepristone are effective drugs for the treatment of uterine fibroids.