老药能够新用,是基于药物通常作用于多个靶点的特性,但其对各个靶点所产生的作用不同,也就会出现有效治疗和副作用的效果。一旦发现其副作用利大于弊,那么一个新适应症就会被挖掘出来。药物发现史上,从抗过敏的老药异丙嗪的镇静作用,开发出了抗精神病的 Old drugs can be new, is based on the drug usually acts on multiple targets, but its effect on each target is different, there will be effective treatment and side effects. Once the side effects are found to outweigh the disadvantages, a new indication will be excavated. In the history of drug discovery, sedative effects of promethazine, an anti-allergy drug, have been developed to combat psychosis