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为探讨不同剂量地塞米松 (Dx)治疗新生儿缺氧缺血性脑病 (HIE)时对患儿血皮质醇 (PTC)和促肾上腺皮质激素(ACTH)的影响 ,采用放射免疫法和固相免疫法 ,分别对17例短程小剂量和16例大剂量Dx治疗组及30例正常新生儿于治疗前 (24h龄内 )和治疗后 (4日龄 )测定血浆PTC和ACTH。结果 :患儿血浆PTC明显升高 (P<0.01) ,大剂量Dx治疗后血PTC明显下降 (P<0.01) ,ACTH则有上升趋势。常规剂量治疗后血PTC下降不明显 ,而ACTH明显增加 (P<0.05)。提示应用短疗程大剂量Dx未发现PTC紊乱及肾上腺皮质功能的抑制。
To investigate the effects of different dosages of dexamethasone (Dx) on plasma cortisol (PTC) and adrenocorticotropic hormone (ACTH) in neonates with hypoxic-ischemic encephalopathy (HIE), radioimmunoassay and solid phase Immunoassay, respectively, 17 cases of short-range low dose and 16 cases of high-dose Dx treatment group and 30 normal neonates before treatment (24h) and after treatment (4 days) plasma PTC and ACTH. Results: The plasma PTC was significantly increased (P <0.01). After the high dose Dx treatment, the blood PTC decreased (P <0.01) and ACTH increased. The decrease of blood PTC after routine dose treatment was not obvious, but ACTH increased obviously (P <0.05). Prompt application of short-course high-dose Dx did not find PTC disorders and inhibition of adrenocortical function.