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本文对7例缓解期急淋患儿加强化疗过程中,通过有关的免疫指标,观察化疗对机体免疫功能的影响。结果指出化疗结束时T细胞数明显降低,B细胞相对增加。NK细胞数及活性均明显降低,一般于化疗停止后二周恢复到化疗前水平。IL-2量在加强化疗后明显降低,停止化疗二周后仍未恢复到化疗前水平。而肿瘤坏死因子和LAK细胞在加强化疗结束时均明显升高,前者在化疗结束后二周恢复化疗前水平,后者仍维持在高水平,超过健康人的正常值。总之化疗时,对不同淋巴细胞群的影响不同,它们之间的关系有待进一步研究。
In this paper, seven patients with acute lymphocytic remission during chemotherapy to strengthen, through the relevant immune indicators to observe the impact of chemotherapy on immune function. The results showed that the number of T cells decreased significantly at the end of chemotherapy, and the relative increase of B cells. NK cell number and activity were significantly reduced, usually two weeks after the cessation of chemotherapy to return to pre-chemotherapy levels. The amount of IL-2 decreased significantly after chemotherapy, and the level of IL-2 did not return to pre-chemotherapy after two weeks of stopping chemotherapy. Tumor necrosis factor and LAK cells were significantly elevated at the end of intensive chemotherapy. The former regained the level of pre-chemotherapy two weeks after the end of chemotherapy, while the latter remained at a high level, exceeding the normal values of healthy people. In short, chemotherapy, the impact of different lymphocyte populations are different, the relationship between them needs further study.